Zanaflex
Brand
name:Zanaflex
Pronounced: ZAN-uh-flecks
Generic name: Tizanidine
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Why
is Zanaflex prescribed?
Tizanidine
relaxes the tense, rigid muscles caused by spasticity. It is
prescribed for people with multiple sclerosis, spinal cord injuries,
and other disorders that produce protracted muscles spasms.
The effect of the drug peaks 1 to 2 hours after each dose and
is gone within 3 to 6 hours, so it's best to schedule doses
for shortly before the daily activities when relief of spasticity
is most important.
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Most
important fact about Zanaflex
Zanaflex
causes drowsiness in almost half the people who use it. It also
tends to reduce blood pressure in many people, frequently leading
to dizziness and light-headedness. The likelihood of significant
drowsiness increases when Zanaflex is combined with other spasticity
drugs, such as Lioresal, Klonopin, and Valium. When taking Tizanidine,
always be cautious about driving or operating dangerous machinery.
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How
should you take Zanaflex ?
Take
Tizanidine exactly as directed. The danger of side effects increases
with the size of the dose.
--If
you miss a dose...
Doses
should be taken only as needed. Allow 6 to 8 hours between doses.
Take no more than 3 a day. Never double the dose.
--Storage
instructions...
Store
at room temperature.
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What
side effects may occur?
Side
effects cannot be anticipated. If any develop or change in intensity,
tell your doctor as soon as possible. Only your doctor can determine
if it is safe to continue using Zanaflex.
More common side effects may include:
Abnormal movements, blurred vision, constipation, dizziness,
drowsiness, dry mouth, flu-like symptoms, frequent urination,
low blood pressure, nervousness, runny nose, slow heartbeat,
sore throat, speech disorders, urinary and other infections,
vomiting, weakness or fatigue
Less common side effects may include:
Abdominal pain, anxiety, back pain, depression, diarrhea, fever,
indigestion, muscle weakness, rash, sores, sweating, tingling
A
number of very rare side effects have also been reported. If
you develop any new or unusual symptoms, be sure to check with
your doctor.
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Why
should Zanaflex not be prescribed?
You'll
need to avoid Tizanidine if it gives you an allergic reaction.
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Special
warnings about Zanaflex
Researchers
have little information on the long-term consequences of using
Zanaflex in single doses of more than 8 milligrams, or in total
amounts of more than 24 milligrams a day. If you require a higher
dosage, previously unrecognized side effects could possibly
appear.
Remember
that Tizanidine can cause low blood pressure and should be used
with caution if you are taking blood pressure medication. Be
cautious, too, when first standing up. Dizziness and light-headedness
are especially likely at that time.
Zanaflex
has been known to cause liver injury in a few patients. If you
have a liver condition, make sure the doctor knows about it.
Alert your doctor immediately if you develop warning signs of
a liver problem such as loss of appetite, nausea, vomiting,
or yellow skin or eyes.
You'll
need a reduced dose of Tizanidine if you have a kidney problem.
Be sure to inform the doctor about your condition, and be quick
to report side effects such as dry mouth, drowsiness, dizziness,
and weakness. They could be signs that your dose is too high.
Use
Zanaflex with caution if spasticity helps you maintain your
posture and balance while walking, or helps to increase other
functions.
Although
there are no reports of eye damage from Tizanidine, it has occurred
in animal tests. Be sure to report any vision problems to your
doctor.
Zanaflex
has not been tested in children.
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Possible
food and drug interactions
Oral contraceptives tend to boost the amount of Zanaflex in
the system. If you are using an oral contraceptive, you'll probably
need a smaller dose of Tizanidine.
Alcohol,
or any drug that slows the nervous system (including other drugs
taken for spasticity), increases the likelihood of drowsiness
when taken with Zanaflex.
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Special
information
The effects of Zanaflex during pregnancy have not been adequately
studied. It should be used during pregnancy only if clearly
needed.
It's
likely that Tizanidine makes its way into breast milk, although
this has not been confirmed. Check with your doctor before using
Zanaflex while nursing.
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Recommended
dosage
ADULTS
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To
minimize side effects, the doctor is likely to begin with a
dosage of 4 milligrams, then increase the dose gradually. Doses
of 8 milligrams provide relief for most people. No more than
3 doses should be taken each 24 hours. The maximum dose per
day is 36 milligrams.
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Overdosage
An
overdose of Tizanidine can impair breathing and lead to coma.
If you suspect an overdose, seek emergency treatment immediately.
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