How
should Sinequan be used?
Sinequan comes as a capsule or concentrate (oral liquid) to take by
mouth. It is usually taken one to three times a day and may be taken
with or without food. Follow the directions on your label
carefully, and ask your doctor or pharmacist to explain any part you
do not understand. Take Sinequan exactly as directed. Do not take
more or less of it or take it more often than prescribed by your doctor.
Doxepin hydrochloride concentrate (oral liquid) comes with a specially
marked dropper for measuring the dose. Ask your pharmacist to show
you how to use the dropper. Dilute the concentrate in 4 ounces (120
ml) of water, whole or skim milk, or orange, grapefruit, tomato, prune,
or pineapple juice just before taking it. Do not mix it with carbonated
beverages (soft drinks). If you take Sinequan concentrate and methadone
syrup, the two liquids can be mixed together with Gatorade, lemonade,
orange juice, Tang, or water but not with grape juice.
Continue
to take Doxepin hydrochloride even if you feel well. Do not stop
taking Sinequan without talking to your doctor, especially if you
have taken large doses for a long time. Your doctor probably will
want to decrease your dose gradually. Doxepin hydrochloride must
be taken regularly for a few weeks before its full effect is felt.
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What
special precautions should I follow?
Before
taking Sinequan, tell your doctor and pharmacist if you are allergic
to Sinequan or any other drugs.
tell your doctor and pharmacist what
drugs you are taking or have taken within the last 2 weeks, especially
antihistamines; anticoagulants [warfarin (Coumadin)]; cimetidine
(Tagamet); estrogens; fluoxetine (Prozac); levodopa (Sinemet, Larodopa);
lithium (Eskalith, Lithobid); MAO inhibitors [phenelzine (Nardil),
tranylcypromine (Parnate)]; medication for high blood pressure,
seizures, Parkinson's disease, diabetes, asthma, colds, or allergies;
methylphenidate (Ritalin); muscle relaxants; oral contraceptives;
sedatives; sleeping pills; thyroid medications; tranquilizers; and
vitamins.
tell your doctor if you have or have ever had glaucoma, an enlarged
prostate, difficulty urinating, diabetes, seizures, an overactive
thyroid gland, or liver, kidney, or heart disease.
tell your doctor if you are pregnant, plan to become pregnant, or
are breast-feeding. If you become pregnant while taking Doxepin
hydrochloride, call your doctor immediately.
if you are having surgery, including dental surgery, tell the doctor
or dentist that you are taking Doxepin hydrochloride.
you should know that Doxepin hydrochloride may make you drowsy.
Do not drive a car or operate machinery until you know how Doxepin
hydrochloride affects you.
remember that alcohol can add to the drowsiness caused by this drug.
tell your doctor if you use tobacco products. Cigarette smoking
may decrease the effectiveness of Doxepin hydrochloride.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it
is almost time for the next dose, skip the missed dose and continue
your regular dosing schedule. Do not take a double dose to make
up for a missed one.
What
side effects can Sinequan cause?
Side effects from Sinequan are common:
upset
stomach
drowsiness
weakness or tiredness
excitement or anxiety
insomnia
nightmares
dry mouth
skin more sensitive to sunlight than usual
changes in appetite or weight
Tell your doctor if any of these symptoms are severe or do not go
away:
constipation
difficulty urinating
frequent urination
blurred vision
changes in sex drive or ability
excessive sweating
If you experience any of the following symptoms, call your doctor
immediately:
jaw,
neck, and back muscle spasms
slow or difficult speech
shuffling walk
persistent fine tremor or inability to sit still
fever
difficulty breathing or swallowing
severe skin rash
yellowing of the skin or eyes
irregular heartbeat
What storage conditions are needed for Sinequan?
Keep Doxepin hydrochloride in the container it came in, tightly
closed, and out of reach of children. Store it at room temperature
and away from excess heat and moisture (not in the bathroom). Throw
away any medication that is outdated or no longer needed. Talk to
your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor and the laboratory.
Your doctor will order certain lab tests to check your response
to sinequan.
Do
not let anyone else take your medication. Ask your pharmacist any
questions you have.
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