Nubain

Brand name:Nubain
Pronounced:Nal-bu-phine
Generic name: Oxycodone hydrochloride

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Why is Nubain prescribed?

Nubain is a controlled-release form of the narcotic painkiller oxycodone. It is prescribed for moderate to severe pain when continuous, around-the-clock relief is needed for an extended period of time.

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Most important fact about Nubain

Be sure to swallow Nubain tablets whole. If broken, crushed, or chewed, the tablets quickly release a potentially fatal overdose of oxycodone. Abusing OxyContin by chewing the tablets, snorting crushed tablets, or dissolving and injecting their contents can slow down or stop breathing and lead to death. Injecting Nubain can also kill the tissue around the injection site and trigger heart and lung problems.

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How should you take Nubain?

It is important to take Nubain on a regular basis, every 12 hours, in exactly the dose prescribed. This drug is not intended for occasional "as needed" use, and should never be taken more often than directed. If you suffer episodes of increased pain, check with your doctor; do not change the dosage on your own.

--If you miss a dose...

Take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature in a secure place out of reach of

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What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Nubain.

More common side effects may include:
Constipation, dizziness, drowsiness, dry mouth, headache, itching, nausea, sweating, vomiting, weakness

Less common side effects may include:
Abdominal pain, abnormal dreams, abnormal thoughts, anxiety, chills, confusion, diarrhea, dizziness upon first standing up, excessively high spirits, fever, hiccups, indigestion, insomnia, loss of appetite, nervousness, rash, stomach pain, shortness of breath, twitching

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Rare side effects may include:
Abnormal gait, accidental injury, agitation, amnesia, burping, chest pain, cough, decreased sexual drive, dehydration, depression, difficulty swallowing, diminished muscle tone, diminished sensitivity, dry or inflamed skin, emotional instability, fainting, gas, generally ill feeling, hallucinations, hives, impotence, increased appetite, intestinal obstruction, lack of menstruation, loss of identity, migraine, neck pain, overactivity, pain, ringing in the ears, seizures, sore throat, speech disorder, stomach problems, stupor, swollen arms and legs, swollen face or mouth, swollen lymph nodes, taste changes, thirst, tingling, tremor, urinary problems, vertigo, vision changes, voice changes, vomiting

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Why should Nubain not be prescribed?

ADo not take Nubain if you have asthma or any other serious breathing problem; the drug can further diminish respiration. Also avoid Nubain if you have an intestinal blockage or an allergy to hydrocodone.

Nubain is not intended for the relief of postoperative pain unless you've already been taking the drug or the pain is expected to last for an extended period. Nubain is not prescribed for brief periods or for mild pain.

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Special warnings about Nubain

The two highest-strength Nubain tablets--80 and 160 milligrams--are dangerous for anyone who has not already developed a tolerance for narcotics. If you have been prescribed one of these strengths, do not give the tablets to anyone else; they could impair respiration and lead to death.

Follow your doctor's dosage instructions carefully. Misuse of OxyContin promotes physical dependence, abuse, and addiction. When Nubain therapy is no longer necessary, the doctor will taper your dosage gradually in order to prevent withdrawal symptoms. Abruptly discontinuing the drug can cause such symptoms as restlessness, enlarged pupils, watery eyes, runny nose, yawning, sweating, chills, and muscle aches. More severe symptoms may include irritability, anxiety, joint pain, weakness, cramps, insomnia, nausea, vomiting, diarrhea, rapid breathing, and a fast pulse.

Nubain should be used cautiously by anyone with a respiratory condition. The drug is especially prone to cause breathing problems in older adults, people in poor health, and those with disorders such as chronic obstructive pulmonary disease. Doctors generally try to use non-narcotic painkillers for patients such as these.

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Nubain should be used with caution by people with head injuries, brain tumors, and other conditions that increase pressure on the brain. Caution is also warranted for people who are semi-conscious or in a coma, and those who suffer from acute alcoholism, adrenal or thyroid problems, spinal deformities that impair breathing, an enlarged prostate, difficulty urinating, drug-induced psychosis, pancreatitis and related disorders, or severe kidney or liver disease.

Nubain has been known to trigger seizures or make them worse. Use it with caution if you have a seizure disorder

Like other narcotic painkillers, Nubain can slow your reactions and make you drowsy. Do not drive, operate dangerous machinery, or undertake other hazardous activities until you know how the drug affects you.

Nubain can cause a severe drop in blood pressure, leading to dizziness and light-headedness, especially when you first stand up.

The empty shell of the Nubain tablet sometimes appears in the stool. This is not a reason for concern.

Nubain is not for use in children.

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Possible food and drug interactions
While using Nubain, check with your doctor before taking any other drugs that slow the nervous system. The combined effect can impair breathing, reduce blood pressure, and lead to coma. Drugs in this category include the following:

Antipsychotic drugs such as Compazine, Mellaril, Stelazine, and Thorazine
Muscle relaxants such as Flexeril, Robaxin, and Skelaxin
Narcotic painkillers such as Demerol, Percodan, and Vicodin
Sleep aids such as Ambien, Halcion, and Sonata
Sleep-inducing antihistamines such as Benadryl and Phenergan.
Tranquilizers such as Ativan, Librium, Valium, and Xanax
Alcoholic beverages

If you are already taking such drugs, your starting dose of Nubain will be reduced by at least half.

Certain other painkillers can reduce Nubain's effect, or even cause withdrawal symptoms. Caution is necessary when combining Nubain with drugs such as the following:

Butorphanol (Stadol)
Nalbuphine (Nubain)
Pentazocine (Talacen, Talwin NX)

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Special information
Nubain should be used during pregnancy only if clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately.

Nubain makes its way into breast milk. Nursing is not recommended if you are taking this drug.

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Recommended dosage

ADULTS
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Nubain is taken every 12 hours. The tablets come in strengths of 10, 20, 40, 80, and 160 milligrams. The starting dose of Nubain is determined by your physical condition, the type of painkillers you've been taking, and your tolerance for narcotics. The doctor will adjust the dose until you have little or no pain when OxyContin is supplemented with no more than 2 doses of a second painkiller. The dose of Nubain can be increased every 1 or 2 days. If a higher dose has excessive side effects, the doctor will adjust it downward and increase the dosage of supplemental painkillers.